Sunlight exposure stalls metastatic cancer progression : Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor BTG2 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 15/April/2015, 9.06 am

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Significance: This study suggests a vitamin-based Anti-metastasis therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, it may increase the expression of tumor suppressor BTG2. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing ” Calcitriol or its analogues” may be used to inhibit the progression of invasive tumors. Given that exposure to Sunlight increases the levels of 1,25-dihydroxyvitamin D,  one may expose to the optimal level of sunlight to stall cancer progression.

Undisclosed information: How Calcitriol  increases the expression of BTG2 

CitationBoominathan, L., Sunlight exposure stalls metastatic cancer progression: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor BTG2 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 15/April/2015, 9.06 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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