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A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 )by Prof Dominic J. Withers, Dr. Selman C and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that: Vitamin-based Life-span extension therapy: ATRA/Tretinoin inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Vitamin-based Life-span extension therapy: ATRA/Tretinoin inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 1/April/2015, 22.13, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests that ATRA/Tretinoin, by increasing the expression of its target gene, it may decrease the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; and (2) insulin sensitivity.   Thus, pharmacological formulations encompassing ATRA/Tretinoin or its analogues may be used to extend the life span of an individual.

Undisclosed information: How ATRA/Tretinoin decreases the expression of p70S6 Kinase

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