Monthly Archives: May 2015

Plumbagin, isolated from the roots of herb Plumbaginaceae, increases the expression of myogenic regulator Myogenin and increases body/muscle size via up regulation of its target gene, 29/May/2015, 11.15 am

A study from the Department of Biochemistry-Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA  shows that “Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size.” This study was published in the 11 … Continue reading

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GOD can give you long life: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene, 29/May/2015, 10.27 am

A study from the Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Diabetes Unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; European Molecular Biology Laboratory, … Continue reading

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Chocolate your way to boost your immunity against cancers: Theobromine, a compound derived from theobroma and commonly found in cocoa and dark chocolates, decreases the expression of PD-1, a suppressor of activation of T-cells, and activates immune system via down regulation of its target gene, 29/May/2015, 10.14 am

A recent study from the Yale Comprehensive Cancer Center, Yale School of Medicine, Cedar Street, New Haven, Connecticut, USA; Dana-Farber/Brigham and Women’s Cancer Center, Brookline Avenue, Boston, Massachusetts, USA; and others shows that “Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in … Continue reading

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Natural product-based therapy for mitigating human preterm birth: I3C, a natural compound found in Broccoli & Brussels, inhibits preterm birth via down regulation of its target gene, 29/May/2015, 9.58 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based therapy for mitigating human preterm birth: I3C, a natural compound found in Broccoli & Brussels, inhibits preterm birth via down regulation of its target gene, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for … Continue reading

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MiRNA-based Anti-ageing therapy: MiRNA-451 increases the expression of immortality gene telomerase via down regulation of its target genes, 29/April/2015, 8.19 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Anti-ageing therapy: MiRNA-451 increases the expression of immortality gene telomerase via down regulation of its target genes, 29/April/2015, 8.19 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has been shown earlier that transgenic expression of … Continue reading

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Natural product-based therapy for T2DM: Phlorotannin, isolated from the edible brown alga Ecklonia stolonifera, enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene, 29/May/2015, 06.35 am

A study from the Clinic for Endocrinology, Diabetes & Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland shows that “Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.” This study was published in the 30 October  2011 issue of … Continue reading

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Small molecule-based Lifespan extension therapy: Bicyclol, an anti-hepatitis drug, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 29/April/2014, 06.26 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: Bicyclol, an anti-hepatitis drug, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 29/April/2014, 06.26 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you … Continue reading

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Natural product-based therapy for Renal cancer: Agaricus blazei Murill (AbM), a medicinal mushroom, suppresses the expression of SPOP via up regulation of its target gene, 28/May/2014, 14.21

A recent study from the Institute for Genomics and Systems Biology, University of Chicago and Argonne National Laboratory, Chicago, Illinois-IL 60637, USA; Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA; and Section on Genetic Medicine, Department of … Continue reading

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MiRNA-based therapy for metabolic diseases: miRNA-142-3p increases muscle mass and the expression of lipolytic genes, and decreases adipose tissue mass via down regulation of its target gene, 28/May/2015, 13.51

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based therapy for metabolic diseases: miRNA-142-3p increases muscle mass and the expression of lipolytic genes,  and  decreases adipose tissue mass via down regulation of its target gene, 28/May/2015, 13.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Natural product-based High-Density lipoprotein therapy: Phloretin, enriched in apple leaves and Manchurian, increases High-Density lipoprotein levels via up regulation of ABCA1, 28/May/2015, 11.51 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based High-Density lipoprotein therapy: Phloretin, enriched in apple leaves and Manchurian, increases High-Density lipoprotein levels via up regulation of ABCA1, 28/May/2015, 11.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first time, that … Continue reading

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Chocolate your way to restore insulin production in T1DM patients: Theobromine, a compound derived from theobroma and commonly found in Cocoa and dark chocolates, promotes the generation of functional insulin-producing cells via down regulation of its target gene, 28/May/2015, 9.24 am

A study from the “Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA” shows that “Generation of functional insulin-producing cells in the gut by Foxo1 ablation.” This study was published in the 11 March  2012 issue of the Journal “Nature Genetics” (the … Continue reading

Comments Off on Chocolate your way to restore insulin production in T1DM patients: Theobromine, a compound derived from theobroma and commonly found in Cocoa and dark chocolates, promotes the generation of functional insulin-producing cells via down regulation of its target gene, 28/May/2015, 9.24 am

Small molecule-based Lifespan extension therapy: Octreotide/Sandostatin, a drug that mimics natural somatostatin, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 28/April/2014, 8.58 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: Octreotide/Sandostatin, a drug that mimics natural somatostatin, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 28/April/2014, 8.58 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Natural product-based Anti-virus therapy: Oleic acid (OA), a Neem oil component, suppresses dengue virus replication via up regulation of its target gene, 28/May/2015, 08.41 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Anti-virus therapy: Oleic acid (OA), a Neem oil component, suppresses dengue virus replication via up regulation of its target gene, 28/May/2015, 08.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first … Continue reading

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Natural product-based Growth hormone therapy: Pear extract increases the expression of Growth hormone (GH) via down regulation of its target gene, 28/May/2015, 07.27 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Growth hormone therapy: Pear extract increases the expression of Growth hormone (GH) via down regulation of its target gene, 28/May/2015, 07.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first time, … Continue reading

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MiRNA-based therapy for Intestinal cancer: MiRNA-100 inhibits metastatic adenocarcinoma via down regulation of Lin28, 28/May/2015, 6.53 am

A recent study from the  Division of Pediatric Hematology/Oncology, Boston Children’s Hospital, Boston, Massachusetts, USA; Dana Farber Cancer Institute, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Boston, Massachusetts, USA shows that “LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal … Continue reading

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MiRNA-based Lifespan extension therapy: MiR-490-3p extends lifespan via down regulation of PAPP-A, 28/April/2014, 06.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based Lifespan extension therapy: MiR-490-3p extends lifespan via down regulation of PAPP-A, 28/April/2014, 06.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: It … Continue reading

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Small molecule-based Life-span extension therapy: Orphan nuclear receptor NUR77 incrases energy expenditure and extends life span by up regulating the expression of FGF21, 28/April/2015, 6.08 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Life-span extension therapy: Orphan nuclear receptor NUR77 incrases energy expenditure and  extends life span by up regulating the expression of  FGF21, 28/April/2015, 6.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Natural product-based therapy for restoring insulin production in T1DM patients: Apo-10′-lycopenoic acid, a metabolite of lycopene, promotes the generation of functional insulin-producing cells via down regulation of its target gene, 27/May/2015, 13.10

A study from the “Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA” shows that “Generation of functional insulin-producing cells in the gut by Foxo1 ablation.” This study was published in the 11 March  2012 issue of the Journal “Nature Genetics” (the … Continue reading

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MiRNA-based Lifespan extension therapy: MiRNA-504 prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 27/April/2014, 11.48 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based Lifespan extension therapy: MiRNA-504 prolongs  mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 27/April/2014, 11.48 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Telmisartan/Micardis, an angiotensin II receptor antagonist, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 27/May/2015, 11.41 am

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of … Continue reading

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