Indian herb Tulsi ameliorates T2DM & extends lifespan: Ursolic acid, enriched in Tulsi [OcimumSanctum Linn] and apples, increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene, 3/May/2015, 12. 33 am

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A study from the Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Diabetes Unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; European Molecular Biology Laboratory, Mouse Biology Unit, 00015-Monterotondo, Italy; and Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK etc.   shows that IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.” This study was published in the 7 Apr  2015 issue of the journal “Cell Metabolism” [the number 1 journal in field of Metabolism with an I.F of 16.747] by Prof. Joseph Avruch, Ning Dai,  and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Indian herb Tulsi ameliorates T2DM & extends lifespan: Ursolic acid, enriched in Tulsi [OcimumSanctum Linn] and apples, increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene. 

Significance: This study suggests, for the first time, that Ursolic acid, by increasing the expression of its target gene, it may (1) decrease diet-induced obesity; (2) increase UCP protein expression;(3) increase energy expenditure; (4) increase cold tolerance; (5) increase glucose tolerance; (6) increase insulin sensitivity; and (7) extend lifespan.  Thus, Ursolic acid may ameliorate T2DM, promote lean mass, increase tolerance to cold exposure, and extend life span of an individual

Undisclosed information: How Ursolic acid increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and promotes longer lifespan

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Indian herb Tulsi ameliorates T2DM & extends lifespan: Ursolic acid, enriched in Tulsi [OcimumSanctum Linn] and apples, increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity, cold exposure tolerance and extends lifespan via up regulation of its target gene, 3/May/2015,  12. 33 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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