Anti-metastasis therapy: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), decreases the expression of PD-1, a suppressor of activation of T-cells, and activates immune system via down regulation of its target gene, 9/May/2015, 14.15

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A recent study from the Yale Comprehensive Cancer Center, Yale School of Medicine, Cedar Street, New Haven, Connecticut, USA; Dana-Farber/Brigham and Women’s Cancer Center, Brookline Avenue, Boston, Massachusetts, USA; and others shows that “Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.” This study was published in the 27 November  2014 issue of Nature (the number 1 journal in Science with an impact factor of 42)  by Prof Hodi FSHerbst RS and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Anti-metastasis therapy: Piceatannol decreases the expression of PD-1, a suppressor of activation of T-cells, and activates immune system via down regulation of its target gene

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Anti-metastasis therapy: Piceatannol , a natural compound found in passion fruit (Passiflora edulis), decreases the expression of PD-1, a suppressor of activation of T-cells, and activates immune system via down regulation of its target gene, 9/May/2015, 14.14, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. 

The study presented here suggests that Piceatannol, a natural compound found in passion fruit (Passiflora edulis), by decreasing the expression of its target gene, it may suppress the expression of PD-1.  Thereby, it may activate immune system and inhibit metastatic progression. Thus, pharmacological formulations encompassing “Piceatannol or its analogues may be used to inhibit the progression of tumors.

Undisclosed information: How  Piceatannol suppresses the expression of PD-1

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