Chocolate your way to restore insulin production in T1DM patients: Theobromine, a compound derived from theobroma and commonly found in Cocoa and dark chocolates, promotes the generation of functional insulin-producing cells via down regulation of its target gene, 28/May/2015, 9.24 am

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A study from the “Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA” shows that “Generation of functional insulin-producing cells in the gut by Foxo1 ablation.” This study was published in the 11 March  2012 issue of the Journal “Nature Genetics” (the no.1 research journal in “Genetics” with an impact factor of  29.648) by Prof. Domenico Accili, Chutima Talchai, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Chocolate your way to restore insulin production in T1DM patients: Theobromine, a compound derived from theobroma and  commonly found in Cocoa and dark chocolates, promotes the generation of functional insulin-producing cells via down regulation of its target gene

Significance:   

Given that: (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find a way to induce regeneration of adult β-cells that were lost in DM.

This study suggests, for the first time, that Theobromine, by increasing the expression of its target gene, it may promote: (1) the generation of functional insulin-producing cells; (2)  secretion of bioactive insulin; and (3)  secretion of C-peptide. Thus, pharmacological formulations encompassing “Theobromine or its analogues” may be used to regenerate human adult β-cells.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Chocolate your way to restore insulin production in T1DM patients: Theobromine, a compound derived from theobroma and  commonly found in Cocoa and dark chocolates, promotes the generation of functional insulin-producing cells via down regulation of its target gene, 28/May/2015, 9.24 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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