Anticancer stem cell therapy: Gremlin-1 increases the expression of stem cell enriched protein Oct-4 via down regulation of its target gene, 10/May/2015, 22.50

Anti-metastasis therapy: 1α,25-dihydroxyvitamin D(3) inhibits migration, invasion and metastasis via down regulation of Roundabout 1, 10/May/2015, 22.45
May 10, 2015
Regenerative therapy for Neurodegenerative diseases: Onion peel extract (OPE) increases Neural progenitor cell (NPC) proliferation and brain size via up regulation of its target gene Lin28, 10/May/2014, 22.56 am
May 10, 2015
Show all

A recent study from the Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Experimental Medicine Division,,  shows that Aberrant epithelial Gremlin-1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. This study was published in the 1 December 2014 issue of the Journal “Nature Medicine” [the number 1 journal in General medicine with an impact factor of 24.973] by Prof. Leedham SJ and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Anticancer stem cell therapy: Gremlin-1 increases the expression of stem cell enriched protein Oct-4 via down regulation of its target gene. This study suggests, for the first time, Gremlin-1, by decreasing the expression of its target gene BMP4, it may : (1) increase the expression of Oct-4; (2) decrease the expression of tumor suppressor miRNAs; and (3) promote cancer stem cell proliferation and self-renewal. Thus, pharmacological formulations encompassing Gremlin-1 inhibitors” may be used to inhibit cancer stem cell proliferation and self-renewal. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, L.,  Anticancer stem cell therapy: Gremlin-1 increases the expression of stem cell enriched protein Oct-4 via down regulation of its target gene, 10/May/2015,  22.50,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Undisclosed information: How Gremlin-1 increases the expression of stem cell enriched protein Oct-4

Comments are closed.