Anticancer stem cell therapy: Gremlin-1 suppresses the expression of tumor suppessor INK4a/ARF via down regulation of its target gene, 22/May/2015, 12.05 am

Small RNAs add more years into your life: MiRNA-34 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via down regulation of its target gene, 21/April/2015, 23.51
May 21, 2015
Small Molecule-based Life extension therapy: AICAR, an analog of AMP, increases catalase expression, decreases oxidative damage and promotes longevity via up regulation of its target gene, 22/May/2015, 12.16 am
May 21, 2015
Show all

A recent study from the Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Experimental Medicine Division,,  shows that Aberrant epithelial Gremlin-1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. This study was published in the 1 December 2014 issue of the Journal “Nature Medicine” [the number 1 journal in General medicine with an impact factor of 24.973] by Prof. Leedham SJ and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Anticancer stem cell therapy: Gremlin-1 suppresses the expression of tumor suppessor INK4a/ARF via down regulation of its target gene. This study suggests, for the first time, Gremlin-1, by suppressing the expression of its target gene BMP4, it may : (1) decrease the expression of INK4a/ARF; and (2) promote cancer stem cell proliferation and self-renewal. Thus, pharmacological formulations encompassing Gremlin-1 inhibitors” may be used to inhibit cancer stem cell proliferation and self-renewal. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, L.,  Anticancer stem cell therapy: Gremlin-1 suppresses the expression of tumor suppessor INK4a/ARF via down regulation of its target gene, 22/May/2015,  12.05 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Undisclosed information: How Gremlin-1 suppresses the expression of tumor suppressor INK4a/ARF

Comments are closed.