A recent study from the Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Experimental Medicine Division,, shows that Aberrant epithelial Gremlin-1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. This study was published in the 1 December 2014 issue of the Journal “Nature Medicine” [the number 1 journal in General medicine with an impact factor of 24.973] by Prof. Leedham SJ and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Anticancer stem cell therapy: Gremlin-1 suppresses the expression of tumor suppessor INK4a/ARF via down regulation of its target gene. This study suggests, for the first time, Gremlin-1, by suppressing the expression of its target gene BMP4, it may : (1) decrease the expression of INK4a/ARF; and (2) promote cancer stem cell proliferation and self-renewal. Thus, pharmacological formulations encompassing “Gremlin-1 inhibitors” may be used to inhibit cancer stem cell proliferation and self-renewal.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, L., Anticancer stem cell therapy: Gremlin-1 suppresses the expression of tumor suppessor INK4a/ARF via down regulation of its target gene, 22/May/2015, 12.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Gremlin-1 suppresses the expression of tumor suppressor INK4a/ARF