Interleukin-based neuropathic pain relieving therapy: Interleukin-1β (IL-1β) inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase, 6/May/2015, 12.11 am

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A recent study from the Pharmacology Institute, University of Heidelberg, Heidelberg, Germany; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA shows that the Serine protease inhibitor-A3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase. This study was published in the 27 April  2015 issue of the Journal “Nature Medicine” (the no.1 journal in General medicine with an impact factor of >28) by Prof.Dr. Kuner, Vicuna and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Interleukin-based neuropathic pain relieving therapy: Interleukin-1β (IL-1β) inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase

Significance:  

The mechanistic basis of Neuropathic pain is far from clear.  This study suggests that, IL-1β, by increasing the expression of its target gene, it may decrease the expression of T cell–derived leukocyte elastase. Thereby, it may relieve neuropathic pain. Thus, pharmacological formulations encompassing IL-1β activators”  may be used to inhibit Neuropathic pain.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan,  Interleukin-based neuropathic pain relieving therapy: Interleukin-1β (IL-1β) inhibits neuropathic pain via down regulation of T cell–derived leukocyte elastase, 6/May/2015, 12.11 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How IL-1β decreases the expression of T cell–derived leukocyte elastase

* Research cooperation

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