Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Lifespan extension therapy: Succinate, a component in the TCA cycle, extends life span by down regulating the expression of Insulin receptor substrate-2, 23/May/2015, 23.49, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests, for the first time, that Succinate, by decreasing the expression of its target gene, it may suppress the expression of Insulin receptor substrate-2. Thereby, it may increase the lifespan of an individual. Thus, pharmacological formulations encompassing “Succinate or its analogues“ may be used to extend the life-span of an individual.
Undisclosed information: How Succinate suppresses the expression of Insulin receptor substrate-2