Lifespan extension therapy: Succinate, a component in the TCA cycle, extends life span by down regulating the expression of Insulin receptor substrate-2, 23/May/2015, 23.49

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Lifespan extension therapy: Succinate, a component in the TCA cycle, extends life span by down regulating the expression of  Insulin receptor substrate-2, 23/May/2015, 23.49, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance:  This study suggests, for the first time, that Succinate, by decreasing the expression of its target gene, it may suppress the expression of Insulin receptor substrate-2. Thereby, it  may increase the lifespan of an individual.  Thus, pharmacological formulations encompassing Succinate or its analogues may be used to extend the life-span of an individual.

Undisclosed information: How Succinate suppresses the expression of  Insulin receptor substrate-2

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