MiRNA-based therapy for metabolic diseases: miRNA-142-3p increases muscle mass and the expression of lipolytic genes, and decreases adipose tissue mass via down regulation of its target gene, 28/May/2015, 13.51

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., MiRNA-based therapy for metabolic diseases: miRNA-142-3p increases muscle mass and the expression of lipolytic genes,  and  decreases adipose tissue mass via down regulation of its target gene, 28/May/2015, 13.51, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

This suggests, for the first time, that miRNA-142-3p, by decreasing the expression of its target gene, it may: (1) increase muscle mass; (2) increase the expression of lipolytic genes in adipose tissues; and (3) decrease adipose tissue mass.  Thus, pharmacological formulations encompassing miRNA-142-3p or its activators may be used to treat metabolic diseases, including obesity.

Undisclosed information: How miRNA-142-3p: (1) increase muscle mass; (2) increase lipolytic genes in adipose tissues; and (3) decrease adipose tissue mass

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