Molecular therapy for Metastatic human tumors: Ndfip1 inhibits cellular proliferation, invasion and metastasis by increasing the expression of metastasis suppressor KRIT1/CCM1 via down regulation of its target gene, 3/May/2015, 23.22

Regenerating the lost cardiomyocytes in Myocardial patients: MiRNA-582-5p increases the expression of ERBB2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 3/May/2014, 23.12
May 3, 2015
Small RNAs not only cure T2DM but also extend lifespan: MiRNA-342 increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and extends lifespan via down regulation of its target gene, 3/May/2015, 23.32
May 3, 2015
Show all

A study from the Cell Pathology Division, The Children’s Hospital of Philadelphia, Philadelphia, USA shows that “TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation.” This study was published in the 15 November  2009 issue of the journal “Nature Immunology” [the number 1 journal in Immunology with an I.F of 24.973] by Prof. Oliver PM, Beal and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Metastatic human tumors: Ndfip1 inhibits cellular proliferation, invasion and metastasis by increasing the expression of metastasis suppressor KRIT1/CCM1  via down regulation of its target gene. 

Significance: This study suggests, for the first time, that adoptor Ndfip1, by decreasing the expression of its target gene, it may increase the expression of KRIT1/CCM1Thus, pharmacological formulations encompassing “Ndfip1 activators” may be used to stall metastatic progression. 

Undisclosed information: How Ndfip1 increases the expression of KRIT1/CCM1

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, Molecular therapy for Metastatic human tumors: Ndfip1 inhibits cellular proliferation, invasion and metastasis by increasing the expression of metastasis suppressor KRIT1/CCM1 via down regulation of its target gene, 3/May/2015,  23.22,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Comments are closed.