Natural product-based therapy for pulmonary diabetic cardiomyopathy: Succinate, one of the component of TCA cycle, inhibits the development of diabetic cardiomyopathy via down regulation of its target gene Foxo1, 1/May/2015, 23.08

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A study from the Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA shows that “Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.” This study was published in the 13 Feb  2012 issue of the journalJournal of Clinical Investigation by Prof. Hill JABattiprolu and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for pulmonary diabetic cardiomyopathy: Succinate, one of the component of TCA cycle, inhibits the development of diabetic cardiomyopathy via down regulation of its target gene Foxo1. 

Significance: It has been shown that cardiovascular disease is the principal cause of death in diabetic patients. This study suggests, for the first time, that Succinate, by increasing the expression of its target gene, it may decrease the expression of its target gene FoxO1. Thereby, it inhibit the development of diabetic cardiomyopathy. Thus, pharmacological formulations encompassing Succinate or its analogues” may be used to diabetic cardiomyopathy.

Undisclosed information: How Succinate decreases the expression of Foxo1 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based therapy for pulmonary diabetic cardiomyopathy: Succinate, one of the component of TCA cycle, inhibits the development of diabetic cardiomyopathy via down regulation of its target gene Foxo1, 1/May/2015,  23.07,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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