Natural product-based therapy for Pulmonary Hypertension: Treatment with Berberine (BBR) reverses pulmonary hypertension via up regulation of BMPR2, 17/April/2015, 23.08

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A recent study from the Department of Pediatrics and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; The Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, CA, USA showsthat “BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survivaland Reverse Pulmonary Hypertension.” This study was published in the 7 April 2015 issue of Cell Metabolism by Prof Rabinovitch M, Diebold I, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Pulmonary Hypertension: Treatment with Berberine (BBR) reverses pulmonary hypertension via up regulation of BMPR2.

Significance:  Deletion of BMPR2 induces/develops: (1)  mitochondrial dysfunction; (2) pro-inflammatory or pro-apoptotic state; and (3) hypoxia-induced pulmonary hypertension. This study suggests, for the first time, that Berberine, by increasing the expression of its target gene BMPR2, it may cause  pulmonary hypertension. Therefore, by treating patients with Berberine, one may induce the expression of BMPR2, increase endothelial cell survival, and inhibit the progression of pulmonary hypertensionTogether, pharmacological formulations encompassing “Berberine or its analogues” may be used to treat pulmonary hypertension. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based therapy for Pulmonary Hypertension: Treatment with Berberine (BBR) reverses pulmonary hypertension via up regulation of BMPR2, 17/April/2015, 23.09,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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