A study from the Clinic for Endocrinology, Diabetes & Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland shows that “Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.” This study was published in the 30 October 2011 issue of the journal “Nature Medicine” [the number 1 journal in General Medicine with an I.F of 24.973] by Prof. Donath MY, Ellingsgaard H and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for T2DM: Oleanolic acid, a natural product isolated from herb Tulsi [OcimumSanctum Linn], enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene
Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find a way to induce regeneration of adult β-cells that were lost in DM.
This study suggests, for the first time, that Oleanolic acid, by increasing the expression of its target gene, it may increase glucagon-like peptide-1 secretion. Thereby, it may increase (1) insulin secretion from L cells and alpha cells; and (2) induce regeneration of insulin-secreting cells. Thus, pharmacological formulations encompassing “Oleanolic acid or its analogues“ may be used to treat T2DM.
Undisclosed information: How Oleanolic acid increases glucagon-like peptide-1 and insulin secretion.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
To cite: Boominathan, Natural product-based therapy for T2DM: Oleanolic acid, a natural product isolated from herb Tulsi [OcimumSanctum Linn], enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene, 24/May/2015, 16.25, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org