Small molecule-based Lifespan extension therapy: Get1 inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 6/May/2015, 11.19 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: Get1 inhibits senescence and extends life span by down regulating the expression of adenylate cyclase 5 (ADCY5), 6/May/2015, 11.20 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: This study suggests, for the first time, that Get1 may extend the […]
Regenerating the lost cardiomyocytes in Myocardial patients: Pitavastatin/Livalo, an inhibitor of HMG-CoA reductase and a blood cholesterol lowering drug, increases the expression of ERBB2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 5/May/2014, 23.57
A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April 2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761) by Prof Tzahor E, D’Uva G, and others. […]
Small RNAs not only cure T2DM but also extend lifespan: MiRNA-146b increases UCP protein expression, energy expenditure, glucose tolerance, insulin sensitivity and extends lifespan via down regulation of its target gene, 5/May/2015, 23.45
A study from the Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Diabetes Unit, Medical Services, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; European Molecular Biology Laboratory, Mouse Biology Unit, 00015-Monterotondo, Italy; Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK […]
Molecular therapy for T2DM: EGFR enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene, 5/May/2015, 23.23
A study from the Clinic for Endocrinology, Diabetes & Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland shows that “Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.” This study was published in the 30 October 2011 issue of the journal “Nature Medicine” [the number 1 journal in General Medicine with an I.F of 24.973] by Prof. Donath MY, Ellingsgaard H and […]
Repairing the damaged DNA by exposing it to the Sunlight: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of DNA repair protein hMSH2 and inhibits tumor development via down regulation of its target gene, 5/May/2015, 22.34
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests a vitamin-based Anti-cancer therapy. 1α, 25-dihydroxyvitamin D3 (Calcitriol), by increasing the expression of its target genes, it may increase the expression of DNA repair protien hMSH2. Thereby, it may inhibit migration and invasion of metastatic cancer cells. Thus, pharmacological formulations encompassing ” Calcitriol or its analogues” may […]
Small molecule-based therapy for p53-deficient tumors: BMP4 suppresses & increases the expression of DNp63α & IAPP (Amylin), respectively, and induces regression of p53-mutated human tumors via down regulation of its target gene, 5/May/2015, 17.43
A recent study from the Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [2] Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA [3] Graduate School of Biomedical Sciences, The University of […]
