Small molecule-based therapy for pulmonary arterial hypertension: Cilostazol inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 21/May/2015, 22.44

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A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small molecule-based therapy for pulmonary arterial hypertension: Cilostazol inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3

Significance:  Cilostazol, by increasing the expression of its target gene, it may decrease the expression of Notch3. Thus, pharmacological formulations encompassing Cilostazol or its analogues” may be used to treat pulmonary arterial hypertension. Given its non-toxic nature compared to other anti-hypertensive drugs, it may be an agent of choice to treat pulmonary arterial hypertension.

Undisclosed information: How Cilostazol decreases the expression of Notch3 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Small molecule-based therapy for pulmonary arterial hypertension: Cilostazol inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 21/May/2015,  22.43,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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