Monthly Archives: June 2015

Regenerative stem cell therapy for Baldness: Taurine, an amino acid, inhibits anagen-to-catagen transition, promotes Keratinocyte Progenitor Cell Expansion and inhibits follicle involution via down regulation of its target gene, 21/June/2015, 11.13 pm

Significance: I have published earlier stating that Taurine may function as a longevity-promoting agent. This study suggests, for the first time, that Taurine, by suppressing the expression of its target gene, it may: (1) increase the expression of keratin genes; (2) inhibit anagen-to-catagen transition, (3) … Continue reading

Posted in Ideas | Comments Off on Regenerative stem cell therapy for Baldness: Taurine, an amino acid, inhibits anagen-to-catagen transition, promotes Keratinocyte Progenitor Cell Expansion and inhibits follicle involution via down regulation of its target gene, 21/June/2015, 11.13 pm

Anti-metastasis therapy: MiRNA-3686 suppresses the expression of matrix metalloproteinase (MMP)-2 and MMP-9 via down regulation of its target gene, 21/June/2015, 10.53 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Anti-metastasis therapy: MiRNA-3686 suppresses the expression of matrix metalloproteinase (MMP)-2 and MMP-9 via down regulation of its target gene, 21/June/2015, 10.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: The study presented here suggests that MiRNA-3686, by … Continue reading

Posted in Ideas | Comments Off on Anti-metastasis therapy: MiRNA-3686 suppresses the expression of matrix metalloproteinase (MMP)-2 and MMP-9 via down regulation of its target gene, 21/June/2015, 10.53 am

Immuno therapy for Cancer: (IFN)-α increases the expression of tumor suppressor PTEN via down regulation of its target gene, 21/June/2015, 9.51 pm

Significance: Tumor suppressor PTEN is the second most mutated gene in human cancer.  This study suggests, for the first time, that (IFN)-α, by suppressing the expression of its target gene, it may increase the expression of PTEN. Thus, pharmacological formulations encompassing “(IFN)-α or its activators” may be used to used to treat human cancers … Continue reading

Posted in Ideas | Comments Off on Immuno therapy for Cancer: (IFN)-α increases the expression of tumor suppressor PTEN via down regulation of its target gene, 21/June/2015, 9.51 pm

Immune enhancement therapy: Urothelial carcinoma-associated 1 (UCA1) increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 20/June/2015, 8.47 am

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the … Continue reading

Posted in Ideas | Comments Off on Immune enhancement therapy: Urothelial carcinoma-associated 1 (UCA1) increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 20/June/2015, 8.47 am

Life-span extension therapy: Rubone inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 19/June/2015, 9.23 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Life-span extension therapy: Rubone inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 19/June/2015, 9.23 am

Natural product-based therapy for Cardiomyopathy: Kaempherol, found in leeks, apples, onions, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/June/2015, 2.15 am

A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.”This study was published in the 2 … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Cardiomyopathy: Kaempherol, found in leeks, apples, onions, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 17/June/2015, 2.15 am

Small molecule-based Lifespan extension therapy: BMP2 increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 15/June/2014, 8.33 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy: BMP2 increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 15/June/2014, 8.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

Posted in Ideas | Comments Off on Small molecule-based Lifespan extension therapy: BMP2 increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 15/June/2014, 8.33 am

Interleukin-based therapy for Age-associated dementia and Alzheimer’s disease (AD): IL-17 increases the expression of AGE receptor 1 (AGER1), the longevity-promoting gene Sirtuin-1 and decreases advanced glycation end products (AGEs) via down regulation of its target gene, 14/June/2015, 9.57 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Interleukin–based therapy for Age-associated dementia and Alzheimer’s disease (AD): IL-17 increases the expression of AGE receptor 1 (AGER1), the longevity-promoting gene Sirtuin-1 and decreases advanced glycation end products (AGEs) via down regulation of its target … Continue reading

Posted in Ideas | Comments Off on Interleukin-based therapy for Age-associated dementia and Alzheimer’s disease (AD): IL-17 increases the expression of AGE receptor 1 (AGER1), the longevity-promoting gene Sirtuin-1 and decreases advanced glycation end products (AGEs) via down regulation of its target gene, 14/June/2015, 9.57 pm

Life-span extension therapy: AMPKα2/PRKAA2 (5′-AMP-activated protein kinase catalytic subunit alpha-2) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 14/June/2015, 9.48 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Life-span extension therapy: AMPKα2/PRKAA2 (5′-AMP-activated protein kinase catalytic subunit alpha-2) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 14/June/2015, 9.48 am

Natural product-based anti-viral therapy: Curcumin, the main component of turmeric, suppresses porcine reproductive and respiratory syndrome virus infection via up regulation of its target gene, 14/June/2015, 9.38 pm

A study from the Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China; and CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of … Continue reading

Posted in Ideas | Comments Off on Natural product-based anti-viral therapy: Curcumin, the main component of turmeric, suppresses porcine reproductive and respiratory syndrome virus infection via up regulation of its target gene, 14/June/2015, 9.38 pm

Small molecule-based Lifespan extension therapy: ZOCOR, a lipid lowering agent, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 14/June/2014, 9.33 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy:ZOCOR, a lipid lowering agent, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 14/June/2014, 9.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite … Continue reading

Posted in Ideas | Comments Off on Small molecule-based Lifespan extension therapy: ZOCOR, a lipid lowering agent, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 14/June/2014, 9.33 am

Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:   Given that (1) … Continue reading

Posted in Ideas | Comments Off on Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm

Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Panax ginseng improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 14/June/2015, 7.20 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: … Continue reading

Posted in Ideas | Comments Off on Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Panax ginseng improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 14/June/2015, 7.20 am

Molecular therapy for Hyperglycemia & T2DM: Panax ginseng increases the expression of AMPK(5′ adenosine monophosphate-activated protein kinase), decreases gluconeogenesis and fasting glucose level via up regulation of its target gene, 14/June/2015, 7.07 am

A recent study from the Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China; & Key Laboratory of Food Safety Risk Assessment, … Continue reading

Comments Off on Molecular therapy for Hyperglycemia & T2DM: Panax ginseng increases the expression of AMPK(5′ adenosine monophosphate-activated protein kinase), decreases gluconeogenesis and fasting glucose level via up regulation of its target gene, 14/June/2015, 7.07 am

Natural product-based therapy for leukaemia: Rhamnetin, an O-methylated flavonol isolated from cloves, suppresess B-cell lineage acute lymphoid leukaemia via up regulation of its target gene, 14/June/2015, 6.40 am

A recent study from the Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143, USA;  and Department of Haematology, University of Cambridge, Cambridge CB2 OAH, UK” shows that Identification of FOXM1 as a therapeutic target in B-cell lineage acute … Continue reading

Comments Off on Natural product-based therapy for leukaemia: Rhamnetin, an O-methylated flavonol isolated from cloves, suppresess B-cell lineage acute lymphoid leukaemia via up regulation of its target gene, 14/June/2015, 6.40 am

Natural product-based Anti-ageing therapy: Kaempherol, found in leeks, apples, and onions, increases the expression of immortality gene telomerase via down regulation of its target genes, 13/June/2015, 11.36 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based Anti-ageing therapy: Kaempherol, found in leeks, apples, and onions, increases the expression of immortality gene telomerase via down regulation of its target genes, 13/June/2015, 11.36 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has been … Continue reading

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Rescuing the cerebral ischemia-mediated brain damage: TGF-β attenuates cerebral ischemia-mediated brain damage via down regulation of its target gene, 13/June/2015, 11.29 pm

A recent study from the Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA shows that “Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage.” This study was published in the 8 May 2015 issue of … Continue reading

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Natural product-based anti-viral therapy: Diallyl trisulfide, a compound isolate from Garlic, suppresses porcine reproductive and respiratory syndrome virus infection via up regulation of its target gene, 13/June/2015, 11.24 pm

A study from the Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China; and CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of … Continue reading

Comments Off on Natural product-based anti-viral therapy: Diallyl trisulfide, a compound isolate from Garlic, suppresses porcine reproductive and respiratory syndrome virus infection via up regulation of its target gene, 13/June/2015, 11.24 pm

Natural product-based Anti-virus therapy: Antrocin, isolated from Antrodia camphorata, suppresses dengue virus replication via up regulation of its target gene, 13/May/2015, 11.17 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Anti-virus therapy: Antrocin, isolated from Antrodia camphorata, suppresses dengue virus replication via up regulation of its target gene, 13/May/2015, 11.17 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first time, … Continue reading

Comments Off on Natural product-based Anti-virus therapy: Antrocin, isolated from Antrodia camphorata, suppresses dengue virus replication via up regulation of its target gene, 13/May/2015, 11.17 pm

Molecular therapy for metastatic breast cancer: Tumor suppressor Grhl3 blocks bone metastasis of mammary cancer via down regulation of its target gene, 13/June/2015, 11.12 pm

A study from the Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark; and Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research, London SW3 6JB, UK shows that “The hypoxic cancer secretome induces pre-metastatic bone … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for metastatic breast cancer: Tumor suppressor Grhl3 blocks bone metastasis of mammary cancer via down regulation of its target gene, 13/June/2015, 11.12 pm