Mechanistic insight into ageing: Advanced glycation end products (AGEs) decrease the expression of longevity-promoting gene Sirtuin-1 and promote insulin resistance via up regulation of their target gene, 11/June/2015, 10.56 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insight into ageing: Advanced glycation end products (AGEs) decrease the expression of longevity-promoting gene Sirtuin-1 and promote insulin resistance via up regulation of its target gene, 11/June/2015, 10.57 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: It has been shown earlier that Advanced glycation end products (AGEs) increase the generation of […]
MiRNA-based therapy for Age-associated dementia and Alzheimer’s disease (AD): MiRNA-638 increases the expression of AGE receptor 1 (AGER1), the longevity-promoting gene Sirtuin-1 and decreases advanced glycation end products (AGEs) via down regulation of its target gene, 11/June/2015, 10.48 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based therapy for Age-associated dementia and Alzheimer’s disease (AD): MiRNA-638 increases the expression of AGE receptor 1 (AGER1), the longevity-promoting gene Sirtuin-1 and decreases advanced glycation end products (AGEs) via down regulation of its target gene, 11/June/2015, 10.48 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that MiRNA-638, by decreasing […]
Natural product-based anti-viral therapy: RITA (reactivation of p53 and induction of tumor cell apoptosis) suppresses porcine reproductive and respiratory syndrome virus infection via up regulation of its target gene, 11/June/2015, 10.41 pm
A study from the Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China; and CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China shows that “Cellular microRNA miR-26a suppresses replication of porcine reproductive […]
Life-span extension therapy: MiRNA-100 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 11/June/2015, 10.38 pm
A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (The number 2 journal in General science with an I.F of […]
MiRNA-based Lifespan extension therapy: RNF2 increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 11/June/2014, 10.31 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based Lifespan extension therapy: RNF2 increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 11/June/2014, 10.33 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: It has been shown earlier that angiotensin II type I receptor […]
Natural product-based therapy for Myopathy: Icariin, a flavanoid and phosphodiestrase-5 inhibitor, induces autophagy, maintains blood sugar during fasting, decreases aging-associated myopathy and mitochondrial dysfunction via up regulation of its target gene, 11/June/2015, 10.26 am
A recent study from the Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Main Street West, Hamilton, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8N 3Z5, Canada shows that “AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging“ This study was published in the 2 […]
