Natural product-based therapy for Cardiomyopathy: Oleic acid , the main component of neem oil, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 12/June/2015, 9.01 am

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A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that Trbp regulates heart function through microRNA-mediated Sox6 repression.”This study was published in the 2 June  2015 issue of the journal “Nature Genetics” (the number 1 research journal in Genetics with an impact factor of 29.648) by Prof. Da-Zhi Wang & Jian Ding, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Cardiomyopathy: Oleic acid, the main component of neem oil, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene

Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were: (i) due to ischemic heart disease; and (ii) expected to be doubled by 2015; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

A number of studies suggests that Cardiomyopathy is the result of altered gene expression of contratile proteins. Trbp, an RNA binding protein, has been shown to be required for normal functioning of heart contractions. Prof Da-Zhi Wang‘s research team has recently shown that inactivation of Trbp in mice leads to prgressive cardiomyopathy and heart failure. 

This study suggests, for the first time, a Natural product-based therapy for Cardiomyopathy.

I have shown earlier that Oleic acid: (1) protects against stress-induced heart failure via up regulation of SNX13; (2) increases life span via up regulation of BubR1 and Sirtuin-1; (3) decreases brain infarct size/damage, edema formation, neutrophil infiltration and promotes neuronal survival via down regulation of TIM-3; (4) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10; (5) increases insulin-secreting cell mass and function; (6) prevents heart failure via down regulation of Type 5-cardiac adenylyl cyclase; (7) promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing the expression of Snai ; (8)  inhibits pulmonary hypertension; and (9)  functions as an anti-cancer agent etc.

This studys suggests, for the first time, that Oleic acid, by increasing the expression of its target gene, it may: (1) increase the expression of Trbp and miRNA-208; (2) decrease the expression of Sox6; (3) increase the expression of cardiac slow-twitch myofiber proteins; (4) decrease the expression of skeletal fast-twitch myofiber proteins (5) restore the balance between slow- and fast-twitch myofiber proteins; and (6) alleviate cardiomyopathy. Thus, pharmacological formulations encompassing “Oleic acid or its analogues” may be used to inhibit prgressive cardiomyopathy and lethal heart failure. Given that Oleic acid treats, as discussed above, a number of related diseases associated with cardiomyopathy and heart failure, it may be an agent of choice to treat cardiomyopathy and heart failure.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based therapy for Cardiomyopathy: Oleic acid, the main component of neem oil, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 12/June/2015,  9.01 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How Oleic acid  induces the expression of Trbp/miR-208. 

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