Life-span extension therapy: Endothelin-1 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 13/June/2015, 10.50 am

Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 13/June/2015, 7.07 am
June 13, 2015
Small molecule-based Lifespan extension therapy: Pitavastatin/Livalo, an inhibitor of HMG-CoA reductase and blood cholesterol lowering drug, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 13/June/2014, 10.54 am
June 13, 2015
Show all

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (The number 2 journal in General science with an I.F of 31.477 )by Prof Dominic J. Withers, Dr. Selman C and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that:  Life-span extension therapy:  Endothelin-1 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, Life-span extension therapy:  Endothelin-1 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 13/June/2015, 10.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Significance: This study suggests that Endothelin-1, by increasing the expression of its target gene, it may decrease the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby, it may promote resistance to bone, immune, and motor dysfunction.   Thus, pharmacological formulations encompassing Endothelin-1  activators may be used to extend the life span of an individual.

Undisclosed information: How Endothelin-1 decreases the expression of p70S6 Kinase

Comments are closed.