MiRNA-based therapy for leukaemia: MiRNA-149 suppresess B-cell lineage acute lymphoid leukaemia via down regulation of its target gene, 10/June/2015, 8.44 pm

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A recent study from the Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143, USA;  and Department of Haematology, University of Cambridge, Cambridge CB2 OAH, UK” shows that Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoid leukaemia. This study was published in the 10 March  2015 issue of the Online journal Nature Communication”  by Prof Müschen M, Buchner M and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based therapy for leukaemia: MiRNA-149 suppresess B-cell lineage acute lymphoid leukaemia via down regulation of its target gene 

Significance: 

This study suggests an miRNA-based therapy for human leukaemia: MiRNA-149, by suppressing the expression of its target gene, it may inhibit the progression of B-cell lineage acute leukaemia. Thus, pharmacological formulations encompassing “MiRNA-149 activators” may be used to inhibit B-cell lineage acute leukaemia.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, MiRNA-based therapy for leukaemia: MiRNA-149  suppresess B-cell lineage acute lymphoid leukaemia via down regulation of its target gene, 10/June/2015, 8.44 pm,Genome-2-Bio-MedicineDiscoverycenter (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How MiRNA-149 inhibits the progression of B-cell lineage acute lymphoid leukaemia.

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