Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 13/June/2015, 7.07 am

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A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural productbased Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10).

Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were: (i) due to ischemic heart disease; and (ii) expected to be doubled by 2015; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

This study suggests, for the first time, a Natural product-based cardiac regeneration therapy.

Kaempherol, a natural flavanoid present in leeks, apples, grapes, tomatoes, green tea, potatoes, onions,broccoli, Brussels sprouts, squash, cucumbers, lettuce,peaches, blackberries, raspberries etc., has been shown to prevent cardiovascular diseases. However, the mechanistic basis of which remains largely unknown. 

This study suggests, for the first time, that Kaempherol, by increasing the expression of its target gene, it may increase the expression of PNUTS/PPP1R10Thereby, it may: (1) inhibit DNA damage responses, (2) inhibit telomere shortening; and (3) promote cardimyocyte survival/regeneration. By treating myocardial patients with Kaempherol, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Thus, pharmacological formulations encompassing Kaempherol or its analogues” may be used to improve cardiac function after myocardial infarction.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 13/June/2015,  7.07 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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* Research cooperation

Undisclosed information: How Kaempherol increases the expression of PNUTS/PPP1R10

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