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Significance:

Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; (3) DM is often associated with a number of other diseases such as diabetic nephropathy, diabetic cardiomyopathy,  diabetic retinopathy, hypertension, myocardial infarction, cardiac hypertrophy etc; and (4) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find better and cheaper drugs–with multifaceted effects–to treat Hyperglycemia & DM.

This study suggests, for the first time, that Ursolic acid, by increasing the expression of its target genes, it may decrease: (1) the expression of Endothelin 1 and TGF-β1; (2) albuminuria and (3) fibronectin protein levels.  Thereby, it may protect against renal and retinal injury in diabetes. Thus, pharmacological formulations encompassing Ursolic acid or its analogues may be used to treat DM.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  Natural product-based therapy for renal and retinal complications in Diabetes: Ursolic acid, enriched in apple peels and Tulsi, protects against renal and retinal injury in diabetes via up regulation of its target gene, 9/June/2015, 7.03 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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