Natural product-based therapy for T2DM: Grape skin ethanol extract (GSE) enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene, 3/June/2015, 10.19 pm

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A study from the Clinic for Endocrinology, Diabetes & Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland shows that Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.” This study was published in the 30 October  2011 issue of the journal “Nature Medicine” [the number 1 journal in General Medicine with an I.F of 24.973] by Prof. Donath MYEllingsgaard H and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for T2DM: Grape skin ethanol extract (GSE) enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene

Significance:

 Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find a way to induce regeneration of adult β-cells that were lost in DM.

This study suggests, for the first time, that Grape skin ethanol extract (GSE), by increasing the expression of its target gene, it may increase glucagon-like peptide-1 secretion.  Thereby, it may increase (1) insulin secretion from L cells and alpha cells;  and (2) induce regeneration of insulin-secreting cellsThus, pharmacological formulations encompassing “Grape skin ethanol extract (GSE) or small molecule compounds isolated from  it may be used to treat T2DM. 

Undisclosed information: How Grape skin ethanol extract (GSE) increases glucagon-like peptide-1 and insulin secretion.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based therapy for T2DM: Grape skin ethanol extract (GSE) enhances insulin secretion by increasing glucagon-like peptide-1 secretion via up regulation of its target gene, 3/June/2015, 10.19 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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