Small molecule-based therapy for Intestinal cancer: PAPD5 opposses proliferative EGFR–SOS1–Ras signals and inhibits the progression of intestinal cancer via up regulation of RasGRP1, 6/June/2015, 1.28 am

A recent study from the  Department of Anatomy, University of California, San Francisco, San Francisco, California, USA shows that “RasGRP1 opposes proliferative EGFR–SOS1–Ras signals and restricts intestinal epithelial cell growth.” This study was published in the 25 May 2015 issue of Nature cell biology  (One of the best research journal in Cell biology with an Impact factor of ~20.761) by Prof. Roose […]

Natural product-based therapy for metastatic breast cancer: EF24, a curcumin analog, blocks bone metastasis of mammary cancer via down regulation of its target gene, 6/June/2015, 12.53 pm

A study from the Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark; and Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research, London SW3 6JB, UK shows that “The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.” This study was published in the 27 May  2015 issue of the journal “Nature” [the number […]

NFKB inhibitors as anti-viral agents: NF-κB augments porcine reproductive and respiratory syndrome virus infection via down regulation of its target gene, 5/June/2015, 10.42 pm

A study from the Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine and State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China; and CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China shows that “Cellular microRNA miR-26a suppresses replication of porcine reproductive […]

MiRNA-based therapy for leukaemia: MiRNA-320 suppresess B-cell lineage acute lymphoid leukaemia via down regulation of its target gene, 5/June/2015, 10.32 pm

A recent study from the Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143, USA;  and Department of Haematology, University of Cambridge, Cambridge CB2 OAH, UK” shows that Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoid leukaemia. This study was published in the 10 March  2015 issue of the Online journal “Nature Communication”  by Prof Müschen […]

Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: Phlorotannin, isolated from the edible brown alga Ecklonia stolonifera, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 5/June/2015, 10.23 pm

A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761) by Prof Tzahor E, D’Uva G, and others. […]

Natural product-based High-Density lipoprotein therapy: Fumigaclavine C increases High-Density lipoprotein levels via up regulation of ABCA1, 5/June/2015, 7.53 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based High-Density lipoprotein therapy: Fumigaclavine C increases High-Density lipoprotein levels via up regulation of ABCA1, 5/June/2015, 7.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This suggests, for the first time, that Fumigaclavine C, by increasing the expression of its target gene ABCA1, it may increase the level of High-Density lipoproteins.  […]