Regenerating the lost pancreatic β-cells in DM patients: MiRNA-196a increases insulin-secreting cell mass and function via down regulation of its target genes, 8/June/2015, 6.00 pm

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Regenerating the lost pancreatic β-cells in DM patients: MiRNA-196a increases insulin-secreting cell mass and function via down regulation of its target genes, 8/June/2015, 6.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

 Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult β-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

This study suggests an miRNA-based Regenerative therapy for DM. MiRNA-196a, by decreasing the expression of its target geneit may increase insulin-secreting cell mass and functionThereby, it may increase insulin sensitivity of cellular tissues.  Thus, pharmacological formulations encompassing “MiRNA-196a activators”  can be used to treat DM.

Undisclosed information: How MiRNA-196a increases insulin-secreting cell mass and function. 

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