Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factorincreases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD),


 Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult β-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

This study suggests a GCSF-based Regenerative therapy for T1DM. GCSFby increasing the expression of its target geneit may increase insulin-secreting cell mass and functionThereby, it may increase insulin sensitivity of cellular tissues.  Thus, pharmacological formulations encompassing “GCSF or its activators”  can be used to treat TIDM.

Undisclosed information: How GCSF increases insulin-secreting cell mass and function. 


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