Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm

Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Panax ginseng improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 14/June/2015, 7.20 am
June 14, 2015
Small molecule-based Lifespan extension therapy: ZOCOR, a lipid lowering agent, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 14/June/2014, 9.33 am
June 14, 2015
Show all

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

CitationBoominathan, Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factorincreases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

 Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult β-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

This study suggests a GCSF-based Regenerative therapy for T1DM. GCSFby increasing the expression of its target geneit may increase insulin-secreting cell mass and functionThereby, it may increase insulin sensitivity of cellular tissues.  Thus, pharmacological formulations encompassing “GCSF or its activators”  can be used to treat TIDM.

Undisclosed information: How GCSF increases insulin-secreting cell mass and function. 

Web: http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Comments are closed.