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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, L., Vitamin-based therapy for Human cancers:1α,25-dihydroxyvitamin D(3) suppresses the expression of MDM4, the negative regulator of p53, via up regulation of its target gene, 5/June/2015, 12.06 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Significance: 

This suggests that α,25-dihydroxyvitamin D(3), by decreasing the expression of its target gene, it may increase the expression of tumor suppressor p53.  Thereby, it may inhibit  cancer cell proliferation. Thus, pharmacological formulations encompassing “α,25-dihydroxyvitamin D(3) or its analogues may be used to inhibit the progression of tumors.

Undisclosed information: How α,25-dihydroxyvitamin D(3) increases the expression of tumor suppressor p53

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