Monthly Archives: August 2015

Natural product-based Lifespan extension therapy: Piperidine alkaloids, isolated from the fruits of P. retrofractum Vahl, activate autophagy and extend lifespan via up regulation of ATG5, 31/Aug/2015, 10.54 pm

A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published in the online journal “Nature communications” by Prof. Jung YK, Pyo Jo and others.  On the foundation of this interesting … Continue reading

Posted in Ideas | Comments Off on Natural product-based Lifespan extension therapy: Piperidine alkaloids, isolated from the fruits of P. retrofractum Vahl, activate autophagy and extend lifespan via up regulation of ATG5, 31/Aug/2015, 10.54 pm

Small molecule-based therapy for increased exercise tolerance and stamina: Apo-10′-lycopenoic acid increases the expression of bidirectional mitochondrial matrix enzyme carnitine acetyltransferase, increases carnitine levels in muscles, and promotes exercise endurance/tolerance via down regulation of its target gene, 31/August/2015, 10.43 pm

A recent study from the Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27704, USA; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University, Durham, NC 27704, USA; Department of Medicine, Division of Endocrinology, … Continue reading

Posted in Ideas | Comments Off on Small molecule-based therapy for increased exercise tolerance and stamina: Apo-10′-lycopenoic acid increases the expression of bidirectional mitochondrial matrix enzyme carnitine acetyltransferase, increases carnitine levels in muscles, and promotes exercise endurance/tolerance via down regulation of its target gene, 31/August/2015, 10.43 pm

MiRNA-based therapy for Idiopathic pulmonary fibrosis: Apoptosis-stimulating protein of p53 (ASPP-1) increases TRF1 expression and ameliorates pulmonary fibrosis via up regulation of its target gene, 31/August/2015, 10.33 pm

A study from the Spanish National Cancer Centre, Melchor Fernández Almagro 3, Madrid, Spain“ shows that: “Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.” This study was published in the 14 July 2015 issue of the journal “Cell Reports” by Prof. Maria, Povedano JM and others. On the foundation of … Continue reading

Posted in Ideas | Comments Off on MiRNA-based therapy for Idiopathic pulmonary fibrosis: Apoptosis-stimulating protein of p53 (ASPP-1) increases TRF1 expression and ameliorates pulmonary fibrosis via up regulation of its target gene, 31/August/2015, 10.33 pm