Small molecule-based therapy for increased exercise tolerance and stamina: Apo-10′-lycopenoic acid increases the expression of bidirectional mitochondrial matrix enzyme carnitine acetyltransferase, increases carnitine levels in muscles, and promotes exercise endurance/tolerance via down regulation of its target gene, 31/August/2015, 10.43 pm

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A recent study from the Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27704, USA; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University, Durham, NC 27704, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University, Durham, NC 27704, USA shows that: Carnitine Acetyltransferase Mitigates Metabolic Inertia and alleviates exercise intolerance. This study was published in the 7 July 2015 issue of the Journal “Cell Metabolism”[the number one research journal in Metabolism with an impact factor of 17.565by Prof. Muoio DM, Seiler SE and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that Small molecule-based therapy for increased exercise tolerance and stamina: Apo-10′-lycopenoic acid increases the expression of bidirectional mitochondrial matrix enzyme carnitine acetyltransferase, increases carnitine levels in muscles,  and promotes exercise endurance/tolerance via down regulation of its target gene

Significance:

It has been shown that Carnitine acetyltransferase is increased during exercise training, while it is decreased during aging and age-related metabolic diseases.  Prof. Muoio DM‘s research team had showed recently that deletion of Carnitine acetyltransferase in muscles results in acetyl-CoA deficit and exercise intolerance, suggesting that induction of Carnitine acetyltransferase  activity may increase the levels of acetylcarnitine and decrease exercise intolerance.

This study suggests, for the first time, that Apo-10′-lycopenoic acid may augment exercise capacity by increasing the expression of carnitine acetyltransferase.

Apo-10′-lycopenoic acid, by increasing the expression of its target gene, it may increase the expression of carnitine acetyltransferase. Thereby, it may: (1) increase acetylcarnitine levels; (2) optimize energy change; (3)  promote exercise tolerance; and (4) mimic or enhance the positive effects of physical exercise or endurance training. Thus, pharmacological formulations encompassing Apo-10′-lycopenoic acid or its analogs” may be used to decrease exercise intolerance or prolong exercise training capacity.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., Small molecule-based therapy for increased exercise tolerance and stamina: Apo-10′-lycopenoic acid increases the expression of bidirectional mitochondrial matrix enzyme carnitine acetyltransferase, increases carnitine levels in muscles,  and promotes exercise endurance/tolerance via down regulation of its target gene, 31/August/2015, 10.43 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How does Apo-10′-lycopenoic acid increase the expression of carnitine acetyltransferase?

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