Natural product-based Lifespan extension therapy: Piperidine alkaloids, isolated from the fruits of P. retrofractum Vahl, activate autophagy and extend lifespan via up regulation of ATG5, 31/Aug/2015, 10.54 pm

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A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published in the online journal “Nature communications” by Prof. Jung YK, Pyo Jo and others. 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that: Natural product-based Lifespan extension therapy: Piperidine alkaloids, isolated from the fruits of P. retrofractum Vahl,  activate autophagy and extend lifespan via up regulation of ATG5

Significance:

This study suggests, for the first time, that Piperidine alkaloids, by increasing the expression of its target gene, it may increase the expression of ATG5. Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features. Thus, pharmacological formulations encompassing “Piperidine alkaloidsmay be used to increase the life span of an individual.

Idea Proposed/Formulated byDr L Boominathan PhD

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To citeBoominathan, Natural product-based Lifespan extension therapy: Piperidine alkaloids, isolated from the fruits of P. retrofractum Vahl,  activate autophagy and extend lifespan via up regulation of ATG5, 31/Aug/2015, 10.54 pm

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