Monthly Archives: September 2016

Natural product therapy for KRAS-mutant lung cancer: γ-Bisabolene, isolated from Cardamom, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 30/September/2016, 1.29 pm

A recent study from the Department of Cell Biology, University of Texas South western Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was published in the 28 September 2016 issue of Nature … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for KRAS-mutant lung cancer: γ-Bisabolene, isolated from Cardamom, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 30/September/2016, 1.29 pm

Molecular therapy for Myocardial Infarction: Long ncRNA-UCA1 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 0(Serine/threonine-protein phosphatase 1 regulatory subunit 10), 30/September/2016, 10.17 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Long ncRNA-UCA1 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 0(Serine/threonine-protein phosphatase 1 regulatory subunit 10), 30/September/2016, 10.17 am

Natural product Life-extension therapy: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officious), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 29/September/2016, 8.13 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Natural product Life-extension therapy: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officious), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 29/September/2016, 8.13 am

Natural product-based Immune enhancement therapy: Vigna nakashimae extract increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 29/September/2016, 8.04 am

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the … Continue reading

Posted in Ideas | Comments Off on Natural product-based Immune enhancement therapy: Vigna nakashimae extract increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 29/September/2016, 8.04 am

Molecular therapy for Myocardial Infarction: Long ncRNA-MALAT1 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 29/September/2016, 7.47 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Long ncRNA-MALAT1 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 29/September/2016, 7.47 am

Natural product Cardiac rejuvenation therapy: Thermostable extract of fenugreek seeds inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 28/September/2016, 10.12 pm

A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March  2015 issue of Nature Communications by Prof Gonzalez, Gonzalez-Valdes and others. On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Natural product Cardiac rejuvenation therapy: Thermostable extract of fenugreek seeds inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 28/September/2016, 10.12 pm

Molecular therapy for Myocardial Infarction: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officious), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/September/2016, 7.37 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officious), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/September/2016, 7.37 pm

Molecular therapy for Myocardial Infarction: Long ncRNA-ADNCR improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/September/2016, 6.42 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Long ncRNA-ADNCR improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/September/2016, 6.42 pm

Anti-telomerase cancer therapy: VHL suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 28/September/2016, 9.27 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: VHL suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 28/September/2016, 9.27 am

Molecular therapy for Myocardial Infarction: Kallistatin improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 27/September/2016, 11.20 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Kallistatin improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 27/September/2016, 11.20 pm

Natural product Cardiac rejuvenation therapy: Oleanolic acid, one of the major constituents of Tulsi [OcimumSanctum Linn], inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 27/September/2016, 11.08 pm

A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March  2015 issue of Nature Communications by Prof Gonzalez, Gonzalez-Valdes and others. On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Natural product Cardiac rejuvenation therapy: Oleanolic acid, one of the major constituents of Tulsi [OcimumSanctum Linn], inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 27/September/2016, 11.08 pm

Natural product Anti-telomerase cancer therapy: Neem leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 27/September/2016, 10.17 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Natural product Anti-telomerase cancer therapy: Neem leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 27/September/2016, 10.17 pm

Natural product Life-extension therapy: Saponin D, an active component isolated from Pulsatilla koreana, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/September/2016, 9.51 pm

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Natural product Life-extension therapy: Saponin D, an active component isolated from Pulsatilla koreana, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/September/2016, 9.51 pm

Natural product Life-span extension therapy: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officinalis), increases life span by suppressing mTOR pathway through up regulation of its target gene, 27/September/2016, 9.33 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org or http://newbioideas.com Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/  Significance:   This study suggests, for the first time, that Carnosic acid, isolated from Rosemary, by suppressing the expression of mTOR, it may: (i) increase autophagic flux; (ii) decrease reactive … Continue reading

Posted in Ideas | Comments Off on Natural product Life-span extension therapy: Carnosic acid (CA), isolated from Rosemary (Rosemarinus officinalis), increases life span by suppressing mTOR pathway through up regulation of its target gene, 27/September/2016, 9.33 pm

Natural product therapy for Myocardial Infarction: (+)-Syringaresinol, isolated from Panax ginseng berry, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 26/September/2016, 10.54 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Myocardial Infarction: (+)-Syringaresinol, isolated from Panax ginseng berry, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 26/September/2016, 10.54 pm

Anti-telomerase cancer therapy: miR-204 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 26/September/2016, 10.29 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Undisclosed information: How MIR-204 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: miR-204 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 26/September/2016, 10.29 pm

Natural product Life-span extension therapy: Thermostable extract of fenugreek seeds increases life span by suppressing mTOR pathway through up regulation of its target gene, 26/September/2016, 10.10 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org or http://newbioideas.com Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/  Significance:   This study suggests, for the first time, that  Thermostable extract of fenugreek seeds, by increasing the expression of its target gene, it may suppress the expression of … Continue reading

Posted in Ideas | Comments Off on Natural product Life-span extension therapy: Thermostable extract of fenugreek seeds increases life span by suppressing mTOR pathway through up regulation of its target gene, 26/September/2016, 10.10 pm

Natural product therapy for pulmonary arterial hypertension: Scutellaria baicalensis inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 26/September/2016, 9.54 pm

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for pulmonary arterial hypertension: Scutellaria baicalensis inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 26/September/2016, 9.54 pm

Regenerating the lost pancreatic β-cells in DM patients: MiRNA-208-3p increases insulin-secreting cell mass and function via down regulation of its target genes, 25/September/2016, 7.25 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Regenerating the lost pancreatic β-cells in DM patients: MiRNA-208-3p  increases insulin-secreting cell mass and function via down regulation of its target genes, 25/September/2016, 7.24 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  Given that (1)  more than 387 … Continue reading

Posted in Ideas | Comments Off on Regenerating the lost pancreatic β-cells in DM patients: MiRNA-208-3p increases insulin-secreting cell mass and function via down regulation of its target genes, 25/September/2016, 7.25 pm

Natural product-based therapy for Cardiomyopathy: Berberine, an alkaloid isolated from the roots and bark of herbs, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 25/September/2016, 7.02 pm

A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This study was published in the 2 … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Cardiomyopathy: Berberine, an alkaloid isolated from the roots and bark of herbs, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 25/September/2016, 7.02 pm