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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Neem leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene

Significance:

Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.

neem2

Neem leaf extract inhibits human cancer cell proliferation via down regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Neem leaf extract, by increasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Thus, this study suggests that pharmacological formulations encompassing Neem leaf extract or a pharmacologically active compound isolated from it may be used to treat human cancers.


CitationBoominathan, L., Natural product Anti-telomerase cancer therapy: Neem leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 27/September/2016, 10.17 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Amount: $150

Undisclosed information: How Neem leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1)

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