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A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the online journal 9 March  2015 issue of Nature Communications by Prof GonzalezGonzalez-Valdes and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Cardiac rejuvenation therapy: Oleanolic acid, one of the major constituents of Tulsi [Ocimum Sanctum Linn], inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene

Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart diseaseand (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free natural product-based drug.

This study suggests, for the first time, a Natural product-based cardiac rejuvenation therapy.

tulsi

Oleanolic acid inhibits dilated cardiomyopathy and heart failure via down regulation of tumor suppressor gene INK4a/p16

This study suggests, for the first time, that Oleanolic acid, by increasing the expression of its target gene, it may suppress the expression of tumor suppressor p16(INK4a)Thereby, it may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility. Thus, by treating myocardial patients with Oleanolic acid, one may prevent Dilated cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function. Thus, pharmacological formulations encompassing Oleanolic acid or its analogues may be used to inhibit dilated cardiomyopathy and heart failure.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org or newbioideas.com

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To citeBoominathan, Natural product Cardiac rejuvenation therapy: Oleanolic acid, one of the major constituents of Tulsi[Ocimum Sanctum Linn], inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 27/September/2016,  11.08 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Oleanolic acid suppresses the expression of tumor suppressor p16(INK4a).

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