A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immnological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Immune enhancement therapy: Berberine increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene. This study suggests, for the first time, Berberine, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing “Berberine or its analogues” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Natural product Immune enhancement therapy: Berberine increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 12/September/2016, 10.29 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Berberine: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?