Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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This study suggests, for the first time, that Berberine, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase the lifespan of an individual. Of interest, decreasing the expression/activity of mTOR has earlier been shown to increase overall lifespan. Together, this study suggests that pharmacological formulations encompassing “Berberine or its analogues” may function as longevity promoters.
To cite: Boominathan, L., Natural product Life-span extension therapy: Berberine, an alkaloid isolated from the roots and bark of herbs, increases life span by suppressing mTOR pathway through up regulation of its target gene, 24/September/2016, 4.44 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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# Research cooperation