Natural product Life-span extension therapy: Berberine, an alkaloid isolated from the roots and bark of herbs, increases life span by suppressing mTOR pathway through up regulation of its target gene, 24/September/2016, 4.44 pm

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Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

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 Significance:  

berberine

Berberine may function as a longevity promoter

This study suggests, for the first time, that  Berberine, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. Of interest, decreasing the expression/activity of mTOR has earlier been shown to increase overall lifespan. Together, this study suggests that pharmacological formulations encompassing Berberine  or its analogues” may function as longevity promoters.

To citeBoominathan, L., Natural product Life-span extension therapy: Berberine, an alkaloid isolated from the roots and bark of  herbs, increases life span by suppressing mTOR pathway through up regulation of its target gene, 24/September/2016, 4.44 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

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