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Idea Proposed/Formulated byDr L Boominathan Ph.D.

Undisclosed information: How Agaricus blazei Murill (AbM) extract  suppresses the expression of Tripeptidyl Peptidase 1 (TPP1)

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The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product therapy for Human Cancer: Agaricus blazei Murill (AbM) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene. 

Significance:

agaricus-blazei-murill

Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.

Agaricus blazei Murill (AbM) extract, by increasing the expression of its target gene, it may decrease the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Considered together, this study suggests that pharmacological formulations encompassing Agaricus blazei Murill (AbM) extract or an active compound isolated from it may be used to treat human cancers.

#Research cooperation


CitationBoominathan, L., Natural product therapy for Human Cancer: Agaricus blazei Murill (AbM) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 20/September/2016, 8.09 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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