Natural product therapy for Myocardial Infarction: Flavanol-rich lychee fruit extract, oligonol, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 18/September/2016, 8.50 am

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lychee-fruit-extract-oligonolA recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for Myocardial Infarction: Flavanol-rich lychee fruit extract, oligonol,  improves myocardial function after myocardial infarction via  up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10)

Significance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; and (3) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars, there is an urgent need to find: (i)  a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free drug.

By treating cardiac patients with lychee fruit extract or oligonol, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing “lychee fruit extract or an active compound isolated from it such as oligonol” may be used to improve cardiac function after myocardial infarction

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Natural product therapy for Myocardial Infarction: Flavanol-rich lychee fruit extract, oligonol,  improves myocardial function after myocardial infarction via  up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 18/September/2016, 8.49 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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# Research cooperation

Undisclosed information: How lychee fruit extract/oligonol increases the expression of PNUTS/PPP1R10

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