Monthly Archives: October 2016

Natural product Lifespan extension therapy: Green tomato extract increases life span via up-regulation of its target gene BubR1, 31/October/2016, 10.18 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint … Continue reading

Posted in Ideas | Comments Off on Natural product Lifespan extension therapy: Green tomato extract increases life span via up-regulation of its target gene BubR1, 31/October/2016, 10.18 pm

Natural product therapy for tuberculosis: Hibiscus syriacus extract increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 31/October/2016, 10.10 pm

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for tuberculosis: Hibiscus syriacus extract increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 31/October/2016, 10.10 pm

Anti-telomerase cancer therapy: MiRNA-124a suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 31/October/2016, 1.52 pm

Introduction: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: MiRNA-124a suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 31/October/2016, 1.52 pm

Natural product therapy for triple-negative breast tumors: Hesperetin, found in citrus peels, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via upd-regulation of its target gene, 31/October/2015, 1.09 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for triple-negative breast tumors: Hesperetin, found in citrus peels, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via upd-regulation of its target gene, 31/October/2015, 1.09 pm

Natural product therapy for Breast Cancer: Amla extract (Emblica officinalis) increases the levels of tumor suppressor p53, inhibits the proliferation of tumor-initiating cells in breast cancer, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 31/October/2015, 6.45 am

A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA shows that “Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Breast Cancer: Amla extract (Emblica officinalis) increases the levels of tumor suppressor p53, inhibits the proliferation of tumor-initiating cells in breast cancer, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 31/October/2015, 6.45 am

Natural product therapy for aged patients with Myocardial Infarction: Onion peel extract induces autophagy in cardiomyocytes, inhibits cardiomyocyte hypertrophy, improves myocardial function in Post myocardial-infarction patients via up-regulation of PPAR-α, PNUTS/PPP1R10 and Sirutin1, 30/October/2016, 11.05 pm

Introduction: What they say A recent study from the Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; and National Heart and Lung Institute, Imperial College, London, United Kingdom … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for aged patients with Myocardial Infarction: Onion peel extract induces autophagy in cardiomyocytes, inhibits cardiomyocyte hypertrophy, improves myocardial function in Post myocardial-infarction patients via up-regulation of PPAR-α, PNUTS/PPP1R10 and Sirutin1, 30/October/2016, 11.05 pm

Natural product therapy for Diabetes mellitus: Isorhapontigenin, isolated from Aiphanes Aculeata, Norway/Sitka/White Spruce, among others, increases islet insulin levels, islet cell mass and glucose tolerance via down-regulation of NMDA receptor GluN2A, 30/October/2016, 6.02 pm

Introduction:  A study from the Institute of Metabolic Physiology, Heinrich Heine University, Düsseldorf, Germany shows that: “Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.” This study was published in the 16 March 2015  issue of the Journal “Nature Medicine” (one of the … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Diabetes mellitus: Isorhapontigenin, isolated from Aiphanes Aculeata, Norway/Sitka/White Spruce, among others, increases islet insulin levels, islet cell mass and glucose tolerance via down-regulation of NMDA receptor GluN2A, 30/October/2016, 6.02 pm

Vitamin-based Lifespan extension therapy: α-Tocopherol (Vitamin-E) increases life span via up-regulation of its target gene BubR1, 30/October/2016, 1.08 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint … Continue reading

Posted in Ideas | Comments Off on Vitamin-based Lifespan extension therapy: α-Tocopherol (Vitamin-E) increases life span via up-regulation of its target gene BubR1, 30/October/2016, 1.08 pm

Natural product therapy for triple-negative breast tumors: Baicalein (5,6,7-trihydroxyflavone), a flavone isolated from the roots of Scutellaria baicalensis/lateriflora and Oroxylum indicum, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 30/October/2015, 12. 02 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for triple-negative breast tumors: Baicalein (5,6,7-trihydroxyflavone), a flavone isolated from the roots of Scutellaria baicalensis/lateriflora and Oroxylum indicum, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 30/October/2015, 12. 02 pm

Molecular therapy for Myocardial Infarction: MiRNA-24 improves myocardial function after myocardial infarction via up-regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 29/October/2016, 8.32 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: MiRNA-24 improves myocardial function after myocardial infarction via up-regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 29/October/2016, 8.32 pm

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: BMP2 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 29/October/2016, 11.11 am

Introduction: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: BMP2 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 29/October/2016, 11.11 am

Small molecule-based PD-1 pathway blockade for Human cancer therapy: DEAR1/TRIM62 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 29/october/2016, 11. 30 am

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in … Continue reading

Posted in Ideas | Comments Off on Small molecule-based PD-1 pathway blockade for Human cancer therapy: DEAR1/TRIM62 inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 29/october/2016, 11. 30 am

Natural product therapy for brain repair and Life-span extension: Ursolic acid, found in Tulsi and apple peels, among others, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 28/October/2016, 9.29 pm

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that “Voluntary Running Triggers … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for brain repair and Life-span extension: Ursolic acid, found in Tulsi and apple peels, among others, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces anti-depressant like effects, and prolongs lifespan via up-regulation of its target gene, 28/October/2016, 9.29 pm

Natural product Lifespan extension therapy: Thermostable extract of fenugreek seeds increases life span via up-regulation of its target gene BubR1, 28/October/2016, 3.04 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint … Continue reading

Posted in Ideas | Comments Off on Natural product Lifespan extension therapy: Thermostable extract of fenugreek seeds increases life span via up-regulation of its target gene BubR1, 28/October/2016, 3.04 pm

Natural product therapy for tuberculosis: α-Lipoic acid, found in broccoli, yams, tomatoes, Brussels sprouts, carrots, and rice bran, among others, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 28/October/2016, 2.46 pm

Introduction: A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of Clinical Investigation” … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for tuberculosis: α-Lipoic acid, found in broccoli, yams, tomatoes, Brussels sprouts, carrots, and rice bran, among others, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 28/October/2016, 2.46 pm

Natural product therapy for Myocardial Infarction: Ampelopsin (AMP), a flavnol mainly found in Ampelopsis grossedentata (commonly known as Mayeam), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/October/2016, 10.29 am

Introduction: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Myocardial Infarction: Ampelopsin (AMP), a flavnol mainly found in Ampelopsis grossedentata (commonly known as Mayeam), improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 28/October/2016, 10.29 am

Anti-telomerase cancer therapy: Bisindole-PBD (Compound 5b) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 28/October/2016, 9.00 am

Introduction: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: Bisindole-PBD (Compound 5b) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 28/October/2016, 9.00 am

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: NURR1 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 28/October/2016, 8.18 am

Introduction: A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of the Journal “Cell” … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: NURR1 promotes an insulin-sensitized state via up-regulation of reprogramming protein Lin28, 28/October/2016, 8.18 am

Natural product-based Combination therapy for Lifespan extension: Green tea extract and Curcumin combo increases life span via up-regulation of its target gene BubR1, 27/October/2016, 2.54 pm

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint … Continue reading

Posted in Ideas | Comments Off on Natural product-based Combination therapy for Lifespan extension: Green tea extract and Curcumin combo increases life span via up-regulation of its target gene BubR1, 27/October/2016, 2.54 pm

Molecular therapy for Myocardial Infarction: BMB2 (Bone morphogenetic protein 2) improves myocardial function after myocardial infarction via up-regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 27/October/2016, 12.29 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: BMB2 (Bone morphogenetic protein 2) improves myocardial function after myocardial infarction via up-regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 27/October/2016, 12.29 pm