Natural product Life-extension therapy: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 2/October/2016, 8.00 am

Anti-telomerase cancer therapy: MIR-138-3p suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 2/October/2016, 7.20 am
October 2, 2016
Natural product therapy for KRAS-mutant lung cancer: Thymoquinone, the most abundant component in Black Cumin – Nigella sativa, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 03/October/2016, 10.59 am
October 3, 2016
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On the eve of Mahatma Gandhi Birth Anniversary

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We wish everyone a happy Mahatma Gandhi Jayanti 2016. On this special occasion, we are happy to announce that Ideas posted today (02/October/2016) will be available to the use of Scientists/Professors/Physicians/Researchers for free. So, there will be no terms and conditions for the ideas posted today (02/October/2016). Each idea posted will be served first come, first served basis. For more details, you may write to us at info@genomediscovery.org

Dr L Boominathan PhD

Director  & CSO, GBMD

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Natural product Life-extension therapy: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Bergapten-isolated-from-Pleurospermum-amabile

Bergapten-isolated-from-Pleurospermum-amabile

Bergapten isolated from Citrus fruits

Bergapten isolated from Citrus fruits

Significance: This study suggests a natural product-based life extension therapy. Bergapten, by increasing the expression of its target gene, it may decrease the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Cialis: ce qu’il peut faire pour vous lorsque vous n’êtes pas tout à fait à la hauteur. Cialis Suisse vs Viagra – Quelle est la différence entre eux?. Thereby,  it may promote (1) resistance to bone, immune, and motor dysfunction; and (2) insulin sensitivity.  

Bergapten

Bergapten

Thus, pharmacological formulations encompassing “Bergapten or it analogues can be used to extend the lifespan of an individual.

CitationBoominathan, Natural product Life-extension therapy: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 2/October/2016, 8.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Undisclosed information: How Bergapten decreases the expression of p70S6 Kinase 

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