A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Immune enhancement therapy: Bone morphogenetic protein 2 (BMP2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene.
This study suggests, for the first time, BMP2, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. Together, pharmacological formulations encompassing “BMP2 activators“ may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance.
Idea Proposed, with factual evidence, by: Dr L Boominathan Ph.D.
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Citation: Boominathan, L., Immune enhancement therapy: Bone morphogenetic protein 2 (BMP2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 25/October/2016, 7.56 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How BMP2: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?