Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 5/October/2016, 10.00 am

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The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene


Significance:

Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.


Honokiol inhibits human cancer cell proliferation via down regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Idea Proposed/Formulated by:

Dr L Boominathan Ph.D.

Honokiol, by increasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Thus, this study suggests that pharmacological formulations encompassing Honokiol or its analogues may be used to

Honokiol

Honokiol

treat human cancers.


CitationBoominathan, L., Natural product Anti-telomerase cancer therapy: Honokiol, a bioactive constituent of Magnolia-grandiflora/dealbata/obovata/officinalis, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 5/October/2016, 10.00 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Amount: $100

Undisclosed information: How Honokiol suppresses the expression of Tripeptidyl Peptidase 1 (TPP1)

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 Attention: Kindly understand that this idea was posted earlier by us, but then we lost it on our website because somebody had hacked our website in the second week of Oct, 2015.  We are in the process of recovering our ideas posted earlier, especially from May, 2015 to October, 2015. So, this idea is re-posted for the sake of the researchers.

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