Natural product Anti-telomerase cancer therapy: Withaferin A (WFA), a natural compound derived from Withania somnifera, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 11/October/2016, 10.48 pm

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The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Withaferin A (WFA), a natural compound derived from Withania somnifera,   suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene


Significance:

Given that cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; (iii) a way to effectively treat cancers that are resistant to anti-cancer drugs; and (iv) a way to effectively treat and eradicate metastatic progression of cancer.


Withaferin A, isolated from Withania somnifera (Ashwagandha), inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Withaferin A, isolated from Withania somnifera (Ashwagandha), inhibits human cancer cell proliferation via down-regulation of Tripeptidyl Peptidase 1 (TPP1) and telomerase

Idea Proposed/Formulated by:

Dr L Boominathan Ph.D.

Withaferin A, by increasing the expression of its target gene, it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1). Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Thus, this study suggests that pharmacological formulations encompassing “Withaferin A or its analogues may be used to treat human cancers.

withaferina


CitationBoominathan, L., Natural product Anti-telomerase cancer therapy: Withaferin A (WFA), a natural compound derived from Withania somnifera,  suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 11/October/2016, 10.48 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Withaferin A (WFA) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1)

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