Natural product-based PD-1 pathway blockade for Human cancer therapy: Isorhapontigenin, isolated from Aiphanes Aculeata, Norway/Sitka/White Spruce, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 27/october/2016, 8.18 am

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Introduction:What they say:

A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in the 28 September 2016 issue of Cancer Discovery (one of the best journals in Cancer Science with an impact factor of 19+) by Prof Andrea L. Cox, Park BV and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based PD-1 pathway blockade for Human cancer therapy: Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka/White Spruce, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene


What is known?

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year recently.


What we say: Research Findings

This study suggests a natural product-based Human cancer therapy.

I had shown earlier that Isorhapontigenin may:(1) prolong mammalian life span via down-regulation of angiotensin II type I receptor and p70 S6 Kinase and up-regulation of BuBR1; (2) promote reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up-regulation of Ngn3; and (3) and inhibit the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3.

Isorhapontigenin, isolated from Strawberry, Mango,  and Cucumber, extends mammalian lifespan via down-regulation of p70S6 Kinase

Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka/White Spruce ,  among others,  suppresses the expression of PD-1 and augments anti-tumor immunity

Isorhapontigenin

Isorhapontigenin

Norway Spruce

Norway Spruce

Sitka spruce

Sitka spruce. Sitka spruce extract slows down aging and increases median lifespan via up-regulation of BuBR1

White spruce (Picea glauca)

White spruce (Picea glauca)

The study presented here suggests that Isorhapontigenin, by decreasing the expression of its target gene, it may suppress the expression of PD-1. Thereby, it may (1) increase the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes; (2) augment anti-tumor activity of the immune system; & (3) inhibit metastatic cancer progression.


Therapeutic opportunity

Given that Natural product Isorhapontigenin has a number of favorable pharmacological health benefits, as discussed above, to human health, it may be a  drug candidate of choice for cancer prevention. Thus, pharmacological formulations encompassing “Isorhapontigenin or its analogs” may be used to inhibit the progression of tumors.


Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, L., Natural product-based PD-1 pathway blockade for Human cancer therapy: Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka/White Spruce, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 27/october/2016, 8.18 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

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Undisclosed information: How Isorhapontigenin suppresses the expression of PD-1 and augments anti-tumor immunity

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