Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 04/October/2016, 7.57 am

Natural product therapy targeting aberrant Lipid synthesis in Human cancers: Ursolic acid, one of the main components of Tulsi and apple peels, suppresses the expression of the principal enzyme in lipid synthesis, ACLY, inhibits aberrant lipid production in cancer cells and tumor progression via up regulation of its target gene, 3/October/2016, 11.37 am
October 3, 2016
Therapeutic insights into PD-1 pathway blockade for Human cancer therapy: Olea europaea leaf extract (OLE) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down regulation of its target gene, 4/October/2016, 10.35 pm
October 4, 2016
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A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via upregulation of its target gene

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Calycosin isolated from the root of Astragalus membranaceous  

Calycosin, isolated from the root of Astragalus membranaceous, may promote longevity via down regulation of p70S6 Kinase

Significance: This study suggests a natural product-based life extension therapy. Calycosin, by increasing the expression of its target gene, it may decrease the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby,  it may promote (1) resistance to bone, immune, and motor dysfunction; and (2) insulin sensitivity.  

Calycosin

Calycosin

Thus, pharmacological formulations encompassing 

Calycosin or it analogues can be used to extend the lifespan of an individual.

CitationBoominathan, Natural product Life-extension therapy: Calycosin, isolated from the root of Astragalus membranaceous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 04/October/2016, 7.57 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org  or http://newbioideas.com

Courtesy: When you cite drop us a line at info@genomediscovery.org

Undisclosed information: How does Calycosin decrease the expression of p70S6 Kinase? 

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