Natural product Life-extension therapy: Fisetin, isolated from Strawberry, Mango, and Cucumber, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span , 18/October/2016, 11.06 pm
Natural product therapy for tuberculosis: Grifolin, isolated from the mushroom Albatrellus confluenes, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation , promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up regulation of its target gene, 18/October/2016, 7.32 am
October 18, 2016Natural product Antisepsis therapy: Hibiscus Syriacus extract increases Sestrin2 expression, inhibits NLRP3 inflammasome activation, and pro-inflammatory cytokines secretion, induces mitophagy in macrophages, and clears damaged mitochondria via autophagic machinery, and protects the host from sepsis via up- regulation of its target gene, 19/October/2016, 2.08 pm
October 19, 2016A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product Life-extension therapy: Fisetin, isolated from Strawberry, Mango, and Cucumber, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Fisetin, isolated from Strawberry, Mango, and Cucumber, extends mammalian lifespan via down-regulation of p70S6 Kinase
Fiestin
Significance: This study suggests a natural product-based life extension therapy. Fisetin, by decreasing the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase), it may promote (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity.
Thus, pharmacological formulations encompassing “Fisetin or its analogues“ can be used to extend the lifespan of an individual.
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Citation: Boominathan, Natural product Life-extension therapy: Fisetin, isolated from Strawberry, Mango, and Cucumber, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span , 18/October/2016, 11.06 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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