Natural product Life-extension therapy: Isorhapontigenin, found in Aiphanes aculeata, Norway spruce (Picea abies), and the Sitka spruce (Picea sitchensis), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span , 22/October/2016, 9.27 am

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A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Natural product Life-extension therapy: Isorhapontigenin, found in Aiphanes aculeata, Norway spruce (Picea abies), and the Sitka spruce (Picea sitchensis), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span 


Idea Proposed/Formulated byDr L Boominathan Ph.D.

I had shown earlier that Isorhapontigenin may:(1) prolong mammalian life span via down-regulation of angiotensin II type I receptor; (2) promote reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up-regulation of Ngn3; and (3) and inhibit the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3.

Isorhapontigenin, isolated from Strawberry, Mango,  and Cucumber, extends mammalian lifespan via down-regulation of p70S6 Kinase

Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka Spruce ,  among others, extends mammalian lifespan via down-regulation of p70S6 Kinase

Isorhapontigenin

Isorhapontigenin

Norway Spruce

Norway Spruce

 

Significance: This study suggests a natural product-based life extension therapy. Isorhapontigenin, by  increasing  the

Sitka spruce

Sitka spruce

expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity.   

Thus, pharmacological formulations encompassing Isorhapontigenin or its analogs can be used to extend the lifespan of an individual.

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CitationBoominathan, Natural product Life-extension therapy: Isorhapontigenin, found in Aiphanes aculeata, Norway spruce (Picea abies), the Sitka spruce (Picea sitchensis), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span , 22/October/2016, 9.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com

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Undisclosed Information: How Isorhapontigenin decreases the expression of p70 S6 Kinase and promotes mammalian life span?

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