Natural product Lifespan extension therapy: Isorhapontigenin, isolated from Aiphanes Aculeata, Norway/Sitka/white Spruce, among others, increases life span via up-regulation of its target gene BubR1, 26/October/2016, 3.18 pm

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 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product Lifespan extension therapy: Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka Spruce ,  among others,  increases life span via up-regulation of its target gene BubR1. 


What we say: Research Findings: 

I had shown earlier that Isorhapontigenin may:(1) prolong mammalian life span via down-regulation of angiotensin II type I receptor and p70 S6 Kinase; (2) promote reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up-regulation of Ngn3; and (3) and inhibit the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3.

Isorhapontigenin, isolated from Strawberry, Mango,  and Cucumber, extends mammalian lifespan via down-regulation of p70S6 Kinase

Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka/White Spruce ,  among others, extends mammalian lifespan via up-regulation of BuBR1

Isorhapontigenin

Isorhapontigenin

Norway Spruce

Norway Spruce

Significance:

This study suggests a natural product-based life extension therapy. 

Sitka spruce

Sitka spruce. Sitka spruce extract slows down aging and increases median lifespan via up-regulation of BuBR1

 

White spruce (Picea glauca)

White spruce (Picea glauca)

Isorhapontigenin, by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Isorhapontigenin or its analogs may be used to extend the lifespan of an individual. 


Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org or http://newbioideas.com

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CitationBoominathan,  Natural product Lifespan extension therapy: Isorhapontigenin, isolated from  Aiphanes Aculeata, Norway/Sitka/white Spruce,  among others,  increases life span via up-regulation of its target gene BubR1, 26/October/2016, 3.18 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Undisclosed information: How Isorhapontigenin increases the expression of BubR1 and extends mammalian life-span

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