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A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product Lifespan extension therapy: Apple extract  increases life span via up-regulation of its target gene BubR1. 

Research Findings: 

Apple tree. Apple extract promotes innate immunity against bacterial infection via up regulation of Sox2

Apple extract slows down aging and increases median lifespan via up-regulation of BuBR1

Apple extract, by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of ageing; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing Apple extract or an active compound isolated from it” may be used to extend the lifespan of an individual. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Natural product Lifespan extension therapy: Natural product Lifespan extension therapy: Apple extract  increases life span via up-regulation of its target gene BubR1, 24/October/2016, 9.48 pm,  Genome-2-Bio-Medicine Discovery center (GBMD),

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Undisclosed information: How Apple extract increases the expression of BubR1 and extends life span

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